Future Outlook
For your patients, an unmet need remains for an FDA-approved agent for R/R PCNSL1-3

FDA-approved therapies indicated for R/R PCNSL are urgently needed

  • There is no accepted standard of care3,4
  • Many patients will experience relapsed or refractory disease and may be ineligible for further intensive treatment due to age, poor performance status, or comorbidities2
  • Outcomes among older patients have remained poor and largely unchanged for decades5,6
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Treating R/R PCNSL Remains a Major Area of Unmet Clinical Need1,2

Advancement in the understanding of 
R/R PCNSL is paramount

  • Current therapeutic knowledge is based on a small number of prospective, multicenter studies1,2,7
  • A limited number of patients are eligible for clinical trials1,2,7
    • Delayed diagnosis of patients can impact inclusion
    • Older age, poor performance status, and comorbidities may disqualify patients
  • Understanding of PCNSL pathobiology is not well established2,7
  • However, recent discoveries have provided targets for drug development, and clinical studies are underway1,2,8

Ono is rising to 
the challenge

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*May include targeted agents, immunomodulatory agents, or other monotherapy/combination regimens.2

†Also a type of chemotherapy.

Not all drugs within the presented classes are used in the treatment of R/R PCNSL.

ASCT=autologous stem cell transplantation; BTKi=Bruton tyrosine kinase inhibitor; FDA=Food and Drug Administration; IMiDs=immunomodulatory drugs; mAbs=monoclonal antibodies; R/R PCNSL=relapsing or refractory primary central nervous system lymphoma; WBRT=whole brain radiation therapy.

References: 1. Tao K, Wang X, Tian X. Relapsed primary central nervous system lymphoma: current advances. Front Oncol. 2021;11;649789. doi.10.3389/fonc.2021.649789 2. Ambady P, Doolittle ND, Fox CP. Relapsed and refractory primary CNS lymphoma: treatment approaches in routine practice. Ann Lymphoma. 2021;5:23. doi:10.21037/aol-21-20 3. Langner-Lemercier S, Houillier C, Soussain C, et al. Primary CNS lymphoma at first relapse/progression: characteristics, management, and outcome of 256 patients from the French LOC network. Neuro Oncol. 2016;18(9):1297-1303. doi:10.1093/neuonc/now033 4. Mendez JS, Grommes C. Treatment of primary central nervous system lymphoma: from chemotherapy to small molecules. Am Soc Clin Oncol Educ Book. 2018;38:604-615. doi:10.1200/EDBK_200829 5. Liu Y, Yao Q, Zhang F. Diagnosis, prognosis and treatment of primary central nervous system lymphoma in the elderly population (review). Int J Oncol. 2021;58(3):371-387. doi:10.3892/ijo.2021.5180 6. Kaulen LD, Baehring JM. Treatment options for recurrent primary CNS lymphoma. Curr Treat Options Oncol. 2022;23(11):1548-1565. doi:10.1007/s11864-022-01016-5 7. Ferreri AJM. How I treat primary CNS lymphoma. Blood. 2011;118(3):510-522. doi:10.1182/blood-2011-03-321349 8. Seidel S, Kowalski T, Nilius-Eliliwi V, Schroers R, Schlegel U. Survival, prognostic factors, hospitalization time and clinical performance status after first cerebral relapse or progression in 54 patients with primary CNS lymphoma not eligible for high dose chemotherapy: a retrospective analysis. Neurol Res Pract. 2023;5(1):8. doi:10.1186/s42466-023-00234-y