Current Treatment Challenges
Navigating Treatment Approaches Can Be Challenging

Although the treatment of PCNSL has evolved during the past few decades, no consensus has been reached on the optimal standard of care in R/R PCNSL.1

Considerations for R/R PCNSL treatments include2:

  • Prior therapies
  • Quality of response to prior therapies
  • Duration of remission

What Are the Challenges With R/R PCNSL Treatment Options?

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Many current treatments in R/R PCNSL can cause significant toxicity3-5

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Elderly patients often have comorbid conditions and treatment can be difficult to tolerate, resulting in poor prognosis5-8

Patients may be unable to tolerate further intensive therapy due to multiple factors2,6,8

  • Debilitating symptoms, such as cognitive impairment and paralysis
  • Advanced age
  • Renal insufficiency
  • Impaired performance status
  • Poor physiological fitness
  • Other comorbidities

The primary recommendation of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for R/R PCNSL is clinical trial participation.9*

There are many options, but...

  • No FDA-approved treatment options2,6
  • No standard of care2,6
  • No preferred regimen, per NCCN Guidelines®6,9

*National Comprehensive Cancer Network® (NCCN®) believes that the best management of any patient with cancer is in a clinical trial.9

NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

What are the obstacles to advancement in 
R/R PCNSL treatment?